Dormicum 15mg – Midazolam

$90.00

Description

Brand Name: Dormicum 15mg – Midazolam

Generic Name: Midazolam

Strength: 15mg

Product Form: Tablets/Pills

Packing Details: Blisters

Manufacturer: Roche
Buy Dormicum 15mg online – Midazolam manufactured by Roche in blister packing.

Buy Dormicum 15mg online.

Contents – Midazolam – Description

Dormicum 15mg – Midazolam tablet contains midazolam maleate while the ampoule contains midazolam HCl.
Each ampoule also contains sodium chloride, hydrochloric acid, sodium hydroxide and water for injection as excipients.
Midazolam is 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4] benzodiazepine.

Action

Short-acting benzodiazepine for premedication, sedation, induction and maintenance of anesthesia.
Tablet: Sleep-inducing agent.

Pharmacology Dormicum 15mg – Midazolam:

Midazolam has a very rapid sedative and sleep-inducing action of pronounced intensity. It also exerts an anxiolytic, an anticonvulsant and a muscle-relaxant effect.
Ampoule: Midazolam is a derivative of the imidazobenzodiazepine group. The free base is a lipophilic substance with low solubility in water.
The basic nitrogen in position 2 of the imidazobenzodiazepine ring system enables midazolam to form water-soluble salts with acids. These produce a stable and well-tolerated injection solution.

The pharmacological action of midazolam is characterized by rapid onset, and because of rapid metabolic transformation, short duration. Because of its low toxicity, midazolam has a wide therapeutic range.
After parenteral administration, anterograde amnesia of short duration occurs (the patient does not recall events that occurred during the peak of activity of the compound).

Pharmacokinetics:

Tablet: Absorption: Dormicum is absorbed rapidly and completely after oral administration. Due to the first-pass effect, bioavailability is approximately 40%.
With a dose of 15 mg, a Cmax of 70-120 ng/mL is reached at Tmax 0.5-1.5 hrs.
Distribution: The concentrations in the plasma decrease in 2 phases with half-lives of 0.3-0.5 hrs (distribution phase) and 1.5-3.5 hrs (elimination phase). 96-98% of midazolam becomes bound to plasma proteins. The volume of distribution ranges from 0.7-1.2 L/kg.
Metabolism: Midazolam is rapidly and completely metabolized. 30-50% of the active ingredient is already metabolized in the course of the first passage through the liver.

The main pharmacologically active metabolite is α-hydroxy midazolam, the elimination half-life of which is shorter than that of the parent substance.
There is no accumulation of midazolam or its active metabolites on prolonged once-daily administration.
Elimination: Midazolam is eliminated via metabolism. The metabolites formed undergo conjugation with glucuronic acid and are eliminated as glucuronides via the kidneys.

Ampoule:

Absorption After IM Injection: Absorption of midazolam from the muscle tissue is rapid and complete. Maximum plasma concentrations are reached within 30 min. Bioavailability is over 90%.
Distribution: When midazolam is injected IV, the plasma concentration-time curve shows 2 distinct phases of distribution. The volume of distribution calculated under steady-state conditions is 0.7-1.2 L/kg body weight. Studies show a protein-binding of 96-98%.
In animals and humans, midazolam has been shown to cross the placenta and to enter fetal circulation. Small quantities of midazolam are found in human milk.

Metabolism:

Midazolam is metabolized rapidly and completely. The primary metabolite is a α-hydroxy-midazolam. The fraction of the dose extracted by liver has been estimated at 40-50%. Many medicaments have been found to inhibit the production of this metabolite in vitro. For some of these drugs, this has been confirmed in vivo (see Interactions).

Elimination:

In healthy volunteers, the elimination half-life is between 1.5 and 2.5 hrs. Plasma clearance is in the range of 300-400 mL/min. When midazolam is given by IV infusion, its elimination kinetics do not differ from those following bolus injection. The elimination half-life of the main metabolite, α-hydroxy-midazolam, is shorter than that of the parent substance. It is conjugated with glucuronic acid (inactivation).

The metabolites are renally excreted.
Pharmacokinetics in Special Clinical Situations: In adults >60 years, the elimination half-life may be prolonged up to 3 times and in some intensive-care patients requiring midazolam by IV infusion for long-term sedation, up to 6 times. In these patients, infusion at an unchanged rate results in higher plasma levels at steady state.

The elimination half-life may also be prolonged in patients with congestive heart failure and with reduced hepatic function.
In children (3-10 years), the elimination half-life is between 1 and 1.5 hrs.
In neonates, the half-life of elimination is prolonged with a mean of 6 hrs (3-12 hrs) due to liver immaturity.

Additional information

count-pills

120 Pills, 60 Pills

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