Description

Brand Name: Dormicum 15mg – Midazolam

Generic Name: Midazolam

Strength: 15mg

Product Form: Tablets/Pills

Packing Details: Blisters

Manufacturer: Roche
Buy Dormicum 15mg online – Midazolam manufactured by Roche in blister packing.

Buy Dormicum 15mg online.

Contents – Midazolam – Description

Dormicum 15mg – Midazolam tablet contains midazolam maleate while the ampoule contains midazolam HCl.
Each ampoule also contains sodium chloride, hydrochloric acid, sodium hydroxide and water for injection as excipients.
Midazolam is 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4] benzodiazepine.

Action

Short-acting benzodiazepine for premedication, sedation, induction and maintenance of anesthesia.
Tablet: Sleep-inducing agent.

Pharmacology Dormicum 15mg – Midazolam:

Midazolam has a very rapid sedative and sleep-inducing action of pronounced intensity. It also exerts an anxiolytic, an anticonvulsant and a muscle-relaxant effect.
Ampoule: Midazolam is a derivative of the imidazobenzodiazepine group. The free base is a lipophilic substance with low solubility in water.
The basic nitrogen in position 2 of the imidazobenzodiazepine ring system enables midazolam to form water-soluble salts with acids. These produce a stable and well-tolerated injection solution.

The pharmacological action of midazolam is characterized by rapid onset, and because of rapid metabolic transformation, short duration. Because of its low toxicity, midazolam has a wide therapeutic range.
After parenteral administration, anterograde amnesia of short duration occurs (the patient does not recall events that occurred during the peak of activity of the compound).

Pharmacokinetics:

Tablet: Absorption: Dormicum is absorbed rapidly and completely after oral administration. Due to the first-pass effect, bioavailability is approximately 40%.
With a dose of 15 mg, a Cmax of 70-120 ng/mL is reached at Tmax 0.5-1.5 hrs.
Distribution: The concentrations in the plasma decrease in 2 phases with half-lives of 0.3-0.5hrs (distribution phase) and 1.5-3.5hrs (elimination phase). 96-98% of midazolam becomes bound to plasma proteins. The volume of distribution ranges from 0.7-1.2 L/kg.
Metabolism: Midazolam is rapidly and completely metabolized. 30-50% of the active ingredient is already metabolized in the course of the first passage through the liver.

The main pharmacologically active metabolite is α-hydroxy midazolam, the elimination half-life of which is shorter than that of the parent substance.
There is no accumulation of midazolam or its active metabolites on prolonged once-daily administration.
Elimination: Midazolam is eliminated via metabolism. The metabolites formed undergo conjugation with glucuronic acid and are eliminated as glucuronides via the kidneys.

Ampoule:

Absorption After IM Injection: Absorption of midazolam from the muscle tissue is rapid and complete. Maximum plasma concentrations are reached within 30 min. Bioavailability is over 90%.
Distribution: When midazolam is injected IV, the plasma concentration-time curve shows 2 distinct phases of distribution. The volume of distribution calculated under steady-state conditions is 0.7-1.2 L/kg body weight. Studies show a protein-binding of 96-98%.
In animals and humans, midazolam has been shown to cross the placenta and to enter fetal circulation. Small quantities of midazolam are found in human milk.

Metabolism:

Midazolam is metabolized rapidly and completely. The primary metabolite is a α-hydroxy-midazolam. The fraction of the dose extracted by liver has been estimated at 40-50%. Many medicaments have been found to inhibit the production of this metabolite in vitro. For some of these drugs, this has been confirmed in vivo (see Interactions).

Elimination:

In healthy volunteers, the elimination half-life is between 1.5 and 2.5 hrs. Plasma clearance is in the range of 300-400 mL/min. When midazolam is given by IV infusion, its elimination kinetics do not differ from those following bolus injection. The elimination half-life of the main metabolite, α-hydroxy-midazolam, is shorter than that of the parent substance. It is conjugated with glucuronic acid (inactivation).

The metabolites are renally excreted.
Pharmacokinetics in Special Clinical Situations: In adults >60 years, the elimination half-life may be prolonged up to 3 times and in some intensive-care patients requiring midazolam by IV infusion for long-term sedation, up to 6 times. In these patients, infusion at an unchanged rate results in higher plasma levels at steady state.

The elimination half-life may also be prolonged in patients with congestive heart failure and with reduced hepatic function.
In children (3-10 years), the elimination half-life is between 1 and 1.5 hrs.
In neonates, the half-life of elimination is prolonged with a mean of 6hrs (3-12hrs) due to liver immaturity.

Buy Dormicum Online Today

Are you tired of tossing and turning every night, desperately seeking the elusive embrace of sleep? Look no further. Dormicum offers a solution that can revolutionize your nights, bringing you the restorative rest you crave. Say goodbye to insomnia’s grip and embrace the promise of rejuvenating sleep with Dormicum.

Understanding Dormicum 15mg – Midazolam

Dormicum, also known as midazolam, belongs to a class of medications called benzodiazepines. It works by enhancing the effects of gamma-aminobutyric acid (GABA), a neurotransmitter in the brain that helps calm the nervous system. This action induces drowsiness, reduces anxiety, and promotes relaxation, making it an effective aid for those struggling with sleep disorders.

The Benefits of Buying Dormicum Online

Convenience is key in today’s fast-paced world, and purchasing Dormicum online offers just that. By buying Dormicum online, you can skip the hassle of visiting a physical pharmacy, saving both time and effort. Additionally, online pharmacies often offer competitive pricing and discreet shipping, ensuring a seamless experience from purchase to delivery.

When Buying Dormicum 15mg – Midazolam Online

While the convenience of online shopping is undeniable, safety should always remain a top priority. When buying Dormicum online, it’s essential to choose a reputable and licensed pharmacy to ensure the authenticity and quality of the medication. Look for pharmacies that require a valid prescription and offer secure payment methods to safeguard your personal information.

Tips for Optimal Sleep Hygiene

While Dormicum can help initiate sleep, incorporating good sleep hygiene practices can further enhance its effectiveness. Here are some tips to optimize your sleep environment:

  1. Create a Relaxing Sleep Environment: Keep your bedroom cool, dark, and quiet to promote restful sleep.
  2. Establish a Consistent Sleep Schedule: Go to bed and wake up at the same time every day, even on weekends, to regulate your body’s internal clock.
  3. Limit Stimulants: Avoid caffeine, nicotine, and electronics before bedtime, as they can interfere with your ability to fall asleep.
  4. Wind Down Before Bed: Engage in relaxing activities such as reading or meditating to signal to your body that it’s time to sleep.

In Conclusion

Don’t let sleepless nights continue to plague your life. Take control of your sleep health today by purchasing Dormicum online. With its proven effectiveness and the convenience of online shopping, better sleep is within reach. Remember to prioritize safety by choosing a reputable online pharmacy, and incorporate good sleep hygiene practices for optimal results. Say goodbye to restless nights and embrace the restorative power of Dormicum.

Additional information

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120 Pills, 60 Pills

10 reviews for Dormicum 15mg – Midazolam

  1. Mikel

    Medication is working fine. I got this few to try it out and i will be needing some more by weekend pls

  2. Cody

    I’m happy you could have them delivered to me all the way here. Your customer service was very helpful.
    Thanks

  3. Launa

    Thanks for delivering my medication safely and in time. Will be needing a refill by the end of the month.

  4. Isobel

    Thanks for making me have this medication. It’s what works for me but my doctors won’t prescribe it. I will be needing more every month.

  5. Hai

    I’m so happy i finally found a place to get the medication i need.

  6. Mellissa

    Your delivery came through a day late. I wasn’t happy about that but your meds are good so i guess that makes up for it.

  7. Dorris

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  8. Cesar

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  9. Penni

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  10. Hilda

    This medication works best for me but the doctors won’t prescribe it for me. Thanks for delivering them to me I will let you know as soon as I need a refill Thanks.

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